论文部分内容阅读
目的分析氟达拉滨治疗慢性淋巴细胞白血病的临床效果.方法21例慢性淋巴细胞白血病患者分别采用不同的用药方式,对不同年龄、性别、分期、治疗方式、疗程的患者以及其他用药史和β2-MG、血清LHD不同情况的患者治疗效果进行比较分析,并对治疗发生的不良反应情况统计.结果60岁以下、女性、Ⅱ期、无其他用药史、5个以上疗程、β2-MG和血清LHD正常患者治疗后总有效率相对更高(P0.05).另外,本组出现1例肝肾功能异常患者,3例中性粒细胞减少患者,2例血小板减少患者;1例口腔溃疡,1例皮肤红斑,1例恶性呕吐,1例便秘患者.结论氟达拉滨治疗慢性淋巴细胞白血病整体疗效较好,值得临床推广.“,”Objective: To analyze the clinical effect of treating chronic lymphocytic leukemia with fludarabine. Methods: Choosed 21 patients of chronic lymphocytic leukemia to treat with different way of using fludarabine. Compared the clinical effect of different paitents by β2-MG, serum LHD, and statistics complication. Results: The patients with under 60 years old, female, I Phase, no other medical history, more than 5 courses, β2-MG, serum LHD normal has better effect (P0.05). There was 1 cases of kidney and liver function abnormal patients, 3 cases of neutropenia patients, 2 cases of thrombocytopenia patients, 1 cases of oral cavity ulcer, 1 cases of skin erythema, 1 cases of malignant vomiting, 1 cases of patients with constipation. Conclusion: Treating chronic lymphocytic leukemia with fludarabine receive good clinical effect to extend in clinic.