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本文重点介绍1983年召开第二届疟疾和巴贝虫病国际会议以来子孢子疫苗研究的进展和成就,这些成就已使合成和重组的亚单位子孢子疫苗用于人类志愿者的临床试验。抗子孢子免疫的特性许多宿主(小鼠、猴和人)通过接种照射子孢子能防御子孢子感染引起的疟疾。这种保护性免疫力有几个特性。(1)种特异性。(2)期特异性。(3)子孢子免疫需要重复接种和大的免疫剂量。(4)免疫接种诱导的抗体能直接针对环子孢子
This article highlights the progress and achievements of the research on sporozoite vaccines since the Second International Conference on Malaria and Babesiosis in 1983, which have resulted in the use of synthetic and recombinant subunit sporozoites in clinical trials of human volunteers. Anti-Sporozoite Immunity Many hosts (mice, monkeys and humans) are protected against malaria caused by sporozoite infection by inoculation with sporozoites. There are several characteristics of this protective immunity. (1) Species-specific. (2) stage specificity. (3) Sporozoite immunization requires repeated inoculations and large immunization doses. (4) immunization induced antibodies can be directed against circumsporozoite spores