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目的研究乙型肝炎患者外周血T淋巴细胞亚群表达情况。方法流式细胞仪检测正常对照组和乙型肝炎患者外周血淋巴细胞CD8、CD28表达。结果正常对照组培养后CD8+CD28+T淋巴细胞明显高于直接检测(P<0.05);培养后慢性乙型肝炎轻中度患者CD8+CD28+T淋巴细胞明显低于直接检测(P<0.05),而CD8+CD28-T淋巴细胞明显高于直接检测(P<0.05)。结论 CD8、CD28表达情况可以作为判断乙型肝炎病情的重要参考依据。
Objective To study the expression of T lymphocyte subsets in peripheral blood of patients with hepatitis B Methods Flow cytometry was used to detect the expression of CD8 and CD28 on peripheral blood lymphocytes in normal control group and Hepatitis B patients. Results CD8 + CD28 + T lymphocytes in normal control group were significantly higher than those in the control group (P <0.05). CD8 + CD28 + T lymphocytes in patients with mild and moderate chronic hepatitis B after culture were significantly lower than those in the direct control group (P <0.05 ), While CD8 + CD28-T lymphocytes were significantly higher than those detected directly (P <0.05). Conclusions The expression of CD8 and CD28 may be used as an important reference for judging the status of hepatitis B.