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目的测定急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI术)后的内皮素-1(ET-1)、人纤溶酶原激活物抑制因子-1(PAI-1)以及高敏C反应蛋白(hs-CRP)浓度,并分析AMI术后伴焦虑抑郁对ET-1、PAI-1及hs-CRP水平的影响。方法选取我院2013年9月至2015年9月期间在接受PCI术治疗的AMI患者200名,按照汉密尔顿焦虑及抑郁量表评分将患者分成介入术后伴焦虑抑郁组(n=103)和介入术后无焦虑抑郁组(n=97)。另选100例未行PCI术治疗患者(对照组)。应用ELASE法测定血清当中内ET-1、PAI-1水平,采用速率散射比浊法测定血清当中hsCRP水平,并对数据进行统计分析。结果 PCI术患者血清ET-1、PAI-1及hs-CRP水平明显高于对照组,且术后伴焦虑抑郁患者明显高于术后无焦虑抑郁的患者。结论 PCI术和焦虑抑郁状态均可能影响患者ET-1、PAI-1及hs-CRP水平。
Objective To determine the expression of endothelin - 1 (ET - 1), human plasminogen activator inhibitor - 1 (PAI-1) and high sensitivity C (CIN) after percutaneous coronary intervention in patients with acute myocardial infarction (Hs-CRP) concentrations in patients with acute myocardial infarction (AMI) and analyze the effect of anxiety and depression on the levels of ET-1, PAI-1 and hs-CRP after AMI. Methods A total of 200 AMI patients undergoing PCI were selected from September 2013 to September 2015 in our hospital. According to the Hamilton Anxiety and Depression Rating Scale, patients were divided into interventional group with anxiety and depression (n = 103) and intervention No postoperative anxiety and depression group (n = 97). Another 100 patients without PCI were treated (control group). The levels of ET-1 and PAI-1 in serum were measured by ELASE method. The serum hsCRP level was measured by rate nephelometry, and the data were statistically analyzed. Results The serum levels of ET-1, PAI-1 and hs-CRP in patients with PCI were significantly higher than those in the control group. The patients with anxiety and depression after PCI were significantly higher than those without postoperative anxiety and depression. Conclusion Both PCI and anxiety and depression status may affect the levels of ET-1, PAI-1 and hs-CRP in patients.