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在动物实验中已发现,脑缺血急性期,血小板表面 P~-选择素(CD62p)、凝血酶敏感蛋白(thrombospondin,TSP)、血小板源内皮细胞粘附分子(CD31)、白细胞表面细胞间粘附分子(ICAM~-1)和血管细胞粘附分子(VCAM~-1)等表达增加,参与脑缺血发病。但在脑缺血患者急性期血中血小板和白细胞表面的上述分子物的变化尚不清楚,我们采用流式细胞术检测活化血小板、白细胞粘附分子,以探讨它们在发病中的变化及其临床意义。
In animal experiments, it has been found that in the acute phase of cerebral ischemia, the levels of CD62p, TSP, CD31, leukocyte surface intercellular adhesion (ICAM ~ -1) and vascular cell adhesion molecule (VCAM ~ -1) expression increased, involved in the pathogenesis of cerebral ischemia. However, in the acute phase of cerebral ischemia in patients with blood platelet and leukocyte surface of the above molecular changes is not clear, we use flow cytometry of activated platelets, leukocyte adhesion molecules to explore their changes in the pathogenesis and clinical significance.