目的 :观察癫患者应用托吡酯单药治疗后 ,脑电背景活动及发作间歇期样放电的变化。方法 :对 42例癫患者给予托吡酯单药治疗 ,比较用药前和用药后 3个月时的脑电背景活动和发作间期样放电的变化及其与临床疗效的关系。结果 :用药 3个月时EEG的θ频段相对功率显著增加(P <0 0 5 ) ,α频段、δ频段、β频段相对功率改变不大 ;4例发作间期的样放电消失 ,6例明显减少 ,但样放电的改变与临床疗效无明显相关性 (P >0 0 5 )。结论 :托吡酯可使脑电背景活动中θ频段相对功率显著增加 ,发作间期的样放电减少 ,但样放电的改变与临床疗效无关 OBJECTIVE: To observe the changes of EEG background activity and intermittent discharge during intermittent episodes of epilepsy in patients with epilepsy. Methods: Twenty-two patients with epilepsy were given topiramate monotherapy. The changes of EEG background activity and interictal discharge before and 3 months after treatment were compared and their relationship with clinical efficacy were compared. Results: The relative power of θ in EEG increased significantly at 3 months (P <0.05), while the relative power in α, δ and β did not change much. The discharge of EEG in 4 cases disappeared, and in 6 cases (P> 0.05). However, there was no significant correlation between the change of discharge and the clinical efficacy (P> 0.05). CONCLUSION: Topiramate can significantly increase the relative power of θ-band in the background of brain electrical activity and reduce the discharge in the interictal phase. However, the change of -like discharge has nothing to do with clinical efficacy