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目的 观察大剂量静脉注射免疫球蛋白 (IVIG)治疗狼疮肾炎 (LN)的疗效。方法 在激素联合环磷酰胺的基础上对观察组 2 9例LN患儿加用IVIG治疗 ,并与对照组 33例LN患儿比较。结果 观察组在降低LN疾病活动性指数计分、血尿及蛋白尿消失、抗核抗体 (ANA)及抗ds-DNA阴转率和降低院内感染率方面明显优于对照组 ,未见明显副作用。结论 IVIG配合激素及环磷酰胺治疗LN是一种有效、安全的方法
Objective To observe the curative effect of high dose intravenous immunoglobulin (IVIG) on lupus nephritis (LN). Methods 29 cases of LN in observation group were treated with IVIG on the basis of hormones combined with cyclophosphamide and compared with 33 cases of LN in control group. Results The observation group was significantly superior to the control group in reducing index of activity index of LN disease, disappearance of hematuria and proteinuria, anti-nuclear antibody (ANA), anti-dsDNA negative conversion rate and reducing nosocomial infection rate. Conclusion IVIG with hormone and cyclophosphamide in the treatment of LN is an effective and safe method