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目的研究藁本属植物茶芎Ligusticum sinense cv.chaxiong地上部位的化学成分。方法综合采用硅胶柱色谱、反相柱色谱及制备HPLC色谱等方法进行分离,利用紫外、质谱及核磁共振谱等方法鉴定化合物的结构。结果从茶芎地上部位的95%乙醇提取物的石油醚和二氯甲烷萃取部位分离得到14个化合物,分别鉴定为5-羟基正丁基苯酞(1)、3-hydroxy-octa-1,5-dien-7-one(2)、伞形花内酯(3)、pumbinernoid A(4)、crocinervolide(5)、(3R,6R,7E)-3-hydroxy-4,7-megastignadien-9-one(6)、洋川芎内酯G(7)、莨菪亭(8)、(2Z)-3-(3,4-二羟基苯基)-2-丙烯醛(9)、(3S,5R,6S,7E,9R)-5,6-epoxy-3,9-dihydroxy-7-megastigmene(10)、吐叶醇(11)、二氢猕猴桃内酯(12)、7-羟基正丁基苯酞(13)、洋川芎内酯A(14)。结论化合物1~13为首次从该植物中分离得到,化合物1、2、4~6和9~13为首次从该属植物中分离得到,化合物1首次作为天然产物分离得到。
Objective To study the chemical constituents of the aerial parts of the genus Ligusticum sinense cv. Chaxiong. Methods The compounds were separated by silica gel column chromatography, reversed phase column chromatography and preparative HPLC. The structures of the compounds were identified by UV, MS and NMR. Results Fourteen compounds were isolated from petroleum ether and dichloromethane extracts of the 95% ethanol extract from the aerial parts of Ligusticum chuanxiong Hort. The compounds were identified as 5-hydroxy-n-butylphthalide (1), 3-hydroxy-octa- (3), pumbinernoid A (4), crocinervolide (5), (3R, 6R, 7E) -3-hydroxy- 4,7-megastignadien-9 (7), scopoletin (8), (2Z) -3- (3,4-dihydroxyphenyl) -2-propenal (9), (3S, 5R , 6S, 7E, 9R) -5,6-epoxy-3,9-dihydroxy-7-megastigmene (10), twofloretin (11), dihydro kiwi lactone (12) Phthalerene (13), Yang Chuanxiong lactone A (14). Conclusions Compounds 1 ~ 13 were isolated from this plant for the first time. Compounds 1, 2, 4 ~ 6 and 9 ~ 13 were isolated from this genus for the first time. Compound 1 was isolated as a natural product for the first time.