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抗生素在临床上应用已有40余年的历史,近年在众多抗生素发展中,引入临床及正在研究的新品种以头孢菌素为最多,特别是第三代头孢类,由于其抗菌谱广尤其某些药物对缘脓杆菌等顽固性革兰氏阴性杆菌感染有较大抗菌作用,加上与氨基糖苷类比其不良反应发生率低,在临床上为治疗很多感染,特别是一些重症感染提供了有力的武器,但是在发挥其治疗作用的同时,临床上不合理使用的现象也非常严重。
Antibiotics have been used clinically for more than 40 years. In recent years, among the many antibiotics, the introduction of new and emerging cephalosporins is the most common, especially the third generation of cephalosporins. Due to its antibacterial spectrum, especially some Drugs on the edge of Pseudomonas aeruginosa and other intractable Gram-negative bacilli infections have a greater antibacterial effect, coupled with the aminoglycoside than the low incidence of adverse reactions in the clinical treatment of many infections, especially some of the severe infections provide a powerful Weapons, but to play its therapeutic role at the same time, the clinical use of the phenomenon is also very serious.