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目的:探讨子宫内膜间质肉瘤的临床病理特征及其鉴别诊断。方法:回顾性分析7例子宫内膜间质肉瘤的临床资料、组织学形态和免疫组化标记并结合文献讨论。结果:患者临床主要症状为不规则阴道出血,病理诊断6例为低级别子宫内膜间质肉瘤,1例为未分化子宫内膜间质肉瘤。低级别子宫内膜间质肉瘤由类似增生期子宫内膜间质的肿瘤细胞构成,并伴有丰富的螺旋小动脉,未分化子宫内膜间质肉瘤则具有明显的细胞异型性,出现较多的坏死及核分裂。结论:子宫内膜间质肉瘤比较少见,无特异性临床表现,诊断主要依靠组织病理学和免疫组化检查。
Objective: To investigate the clinicopathological features and differential diagnosis of endometrial stromal sarcoma. Methods: A retrospective analysis of 7 cases of endometrial stromal sarcoma clinical data, histological morphology and immunohistochemical markers combined with the literature discussion. Results: The main clinical symptoms of patients with irregular vaginal bleeding, pathological diagnosis of 6 cases of low-grade endometrial stromal sarcoma, 1 case of undifferentiated endometrial stromal sarcoma. Low-grade endometrial stromal sarcoma is formed by similar proliferative endometrial stromal tumor cells, accompanied by a rich spiral arteries, undifferentiated endometrial stromal sarcoma has a significant cell atypia, there are more Necrosis and mitosis. Conclusion: Endometrial stromal sarcoma is relatively rare and has no specific clinical manifestations. The diagnosis mainly depends on histopathology and immunohistochemistry.