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观察了２１例原发性高血压病人口服可乐宁前后血小板胞浆游离钙、血浆去甲肾上腺素（ＮＥ）、血浆血管紧张素Ⅱ（ＡＴⅡ）、肾上腺素诱导的血小板聚集率的变化。结果发现，高血压病人上述指标均比正常人明显增高，血小板胞浆内游离钙增高程度与血压增高呈正相关，其余３项指标增高程度与血压增高程度无明显相关。可乐宁治疗后高血压病人ＮＥ水平明显降低，但细胞游离钙无明显变化。提示交感神经活性增加、细胞内游离钙增高作为两个独立的因子参与高血压发病。
The changes of platelet cytoplasmic free calcium, plasma norepinephrine (NE), plasma angiotensin Ⅱ (ATⅡ) and adrenaline-induced platelet aggregation in 21 patients with essential hypertension were observed before and after oral administration of clonidine. The results showed that the above indicators were significantly higher in hypertensive patients than in normal subjects. The increase of intracellular free calcium in platelets was positively correlated with the increase of blood pressure. There was no significant correlation between the increase of the other three indexes and the increase of blood pressure. The level of NE in hypertensive patients after treatment with clonidine was significantly lower, but the cell free calcium did not change significantly. Suggesting that increased sympathetic activity, intracellular free calcium increased as two independent factors involved in the pathogenesis of hypertension.