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目的分析IL-6基因-634位点C/G替换单核苷酸多态性与脑出血的关系。方法采用PCR和RFLP方法检测596例脑出血及335例正常对照者IL-6基因-634位点多态性。结果湖南汉族人群中,IL-6基因-634位点存在GG、GC、CC基因型,其不同基因型频率及等位基因频率在脑出血组和对照组间差异无统计学意义(P>0.05)。结论中国湖南汉族人群中,IL-6-634C/G基因多态性可能与脑出血的发病无关。
Objective To analyze the relationship between IL-6 gene -634 site C / G replacement single nucleotide polymorphism and cerebral hemorrhage. Methods The polymorphisms of IL-6 gene-634 in 596 patients with cerebral hemorrhage and 335 healthy controls were detected by PCR and RFLP. Results There were GG, GC and CC genotypes at IL-6 gene-634 locus in Hunan Han population. The frequencies of different genotypes and allele frequencies were not significantly different between cerebral hemorrhage group and control group (P> 0.05 ). Conclusion The polymorphism of IL-6-634C / G gene in Chinese Han nationality in Hunan Province may not be related to the incidence of cerebral hemorrhage.