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目的：探讨动态监测气道闭合压（Ｐ０．１）在预测成功脱机中的应用意义。方法：各种呼吸衰竭需要机械通气患者在应用压力支持通气（ＰＳＶ）脱机时，每８小时测定１次Ｐ０．１，同时记录患者的潮气量（ＶＴ）、通气量（ＶＥ）、呼吸频率（ＲＲ）、潮气末二氧化碳分压（ＥＴＣＯ２）、经皮血氧饱和度（ＳｐＯ２），以及压力支持（ＰＳ）水平，将患者分为脱机成功组（２４例）和脱机失败组（１６例）进行对照分析。结果：在ＰＳＶ期间，脱机成功组Ｐ０．１、ＶＥ均无明显变化（Ｐ＞０．０５）；脱机失败组Ｐ０．１结束前值（０．７５±０．３６ｋＰａ，１ｋＰａ＝１０．２０ｃｍＨ２Ｏ）与基础值（０．４１±０．２８ｋＰａ）以及与脱机成功组同期值（０．２７±０．０９ｋＰａ，０．２８±０．１５ｋＰａ）比较均明显升高（Ｐ均＜０．０１），ＶＥ较脱机成功组明显升高（Ｐ＜０．０５）。Ｐ０．１与ＶＥ明显相关（ｒ＝０．６２，Ｐ＜０．０５）。结论：动态观察Ｐ０．１，对于常规参数处于边缘值欲脱机患者将可明显提高脱机成功率。
Objective: To explore the significance of dynamic monitoring of airway pressure (P0.1) in predicting successful off-line. Methods: All patients with mechanical respiratory failure requiring mechanical ventilation were assessed for P0.1 every 8 hours while using PSV, and the patient’s tidal volume (VT), ventilation (VE), and respiratory rate The patients were divided into two groups: off-line success (24 cases) and off-line failure (16 cases) Cases) for comparative analysis. Results: There was no significant change of P0.1 and VE in the successful off-line group during PSV (P> 0.05), while the value of P0.1 in off-line failure group (0.75 ± 0.36kPa and 1kPa = 10) 20cmH2O) were significantly higher than baseline values (0.41 ± 0.28kPa) and those of the successful off-line group (0.27 ± 0.09kPa, 0.28 ± 0.15kPa) (all P <0. 01), VE was significantly higher than the successful off-line group (P <0.05). P0.1 was significantly associated with VE (r = 0.62, P <0.05). Conclusion: The dynamic observation of P0.1, for the conventional parameters at the edge of the value of patients who will be off-line will be significantly increased off-line success rate.