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在多聚磷酸(PPA)存在下,2,6-二烷氧基(羟基)苯乙酮的苄腙和甲腙可以发生环化反应,生成产率较高的吲唑类化合物。根据实验结果,我们推测反应的关键步骤为亲核进攻。化合物的结构均经元素分析、IR、~1HNMR和MS确定。
Benzylhydrazone and methylhydrazone of 2,6-dialkoxy (hydroxy) acetophenone can undergo cyclization reaction in the presence of polyphosphoric acid (PPA) to produce indazole compounds with higher yield. Based on the experimental results, we speculate that the key step of the reaction is nucleophilic attack. The structures of the compounds were confirmed by elemental analysis, IR, ~ 1HNMR and MS.