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目的:探讨早产儿血清降钙素原(PCT)、白细胞介素-6(IL-6)水平变化对早产儿细菌感染性疾病及解脲支原体(UU)感染的诊断价值。方法:选择在该院住院诊治的早产儿共110例,按出院诊断分为细菌感染组和对照组(非细菌感染组)各40例,UU感染组30例,所有新生儿于生后6~12 h采血检测PCT、IL-6、C反应蛋白(CRP)。结果:细菌感染组血清PCT、IL-6、CRP水平明显升高,与UU感染组比较差异有统计学意义,与对照组比较差异有统计学意义(P<0.01);而UU感染组血清PCT、IL-6水平明显升高,与对照组比较差异有统计学意义(P<0.01)。与CRP比较,PCT、IL-6在诊断细菌感染灵敏度方面优于CRP,而特异度不如CRP。PCT、IL-6在诊断UU感染方面灵敏度及特异度都不高。结论:PCT、IL-6有助于早产儿全身性细菌感染的早期诊断,具有较高的敏感性。有助于指导临床及时合理应用抗生素。
Objective: To investigate the changes of serum procalcitonin (PCT) and interleukin-6 (IL-6) levels in preterm infants in the diagnosis of bacterial infectious diseases and ureaplasma urealyticum (UU) infection in premature infants. Methods: A total of 110 preterm infants diagnosed and treated in the hospital were selected. According to the diagnosis of discharge, 40 cases were divided into bacterial infection group and control group (non-bacterial infection group), 30 cases were UU infection group, Blood samples were collected for detection of PCT, IL-6 and C-reactive protein (CRP) at 12 h. Results: The levels of serum PCT, IL-6 and CRP in bacterial infection group were significantly higher than those in UU infection group (P <0.01), but the difference was statistically significant , IL-6 levels were significantly increased, compared with the control group, the difference was statistically significant (P <0.01). Compared with CRP, PCT, IL-6 in the diagnosis of bacterial infection sensitivity is superior to CRP, but less specific than CRP. PCT, IL-6 in the diagnosis of UU infection sensitivity and specificity are not high. Conclusion: PCT and IL-6 contribute to the early diagnosis of systemic bacterial infection in preterm infants with high sensitivity. Help to guide clinical timely and rational use of antibiotics.