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缝隙连接是存在于相邻细胞间的膜通道结构,它的基本组成单位是连接蛋白。缝隙连接不仅在细胞间起机械连接作用,它还可以通过电偶联和化学偶联两种方式介导细胞间电和化学信号的传递,当机体受到外部或内部刺激后,缝隙连接可以通过改变连接蛋白的表达使机体适应这种变化。连接蛋白的磷酸化状态与缝隙连接形成密切相关,MAPK,PKC,c-Src,PKA和CK1等激酶可以磷酸化连接蛋白,并调节缝隙连接的功能。血管内皮细胞(VEC)与平滑肌细胞(VSMC)间的缝隙连接被称为肌内皮缝隙连接(MEGJ),它可以穿过内弹力层使VEC和VSMC进行直接的电和化学信号交流,VEC通过MEGJ实现其调节血管张力的功能。缝隙连接交流参与了失血性休克后血管低反应性的调节。
Gap junction is the membrane channel structure existing in adjacent cells, and its basic constituent unit is connexin. Gap junction not only plays the role of mechanical connection between cells, but also can mediate the transmission of electrical and chemical signals between cells through electric coupling and chemical coupling. When the body is stimulated externally or internally, the gap junction can be changed by changing The expression of connexins allows the body to adapt to this change. The phosphorylation status of connexin is closely related to the formation of gap junctions. Kinase such as MAPK, PKC, c-Src, PKA and CK1 can phosphorylate connexin and regulate the function of gap junctions. The gap junction between vascular endothelial cells (VECs) and smooth muscle cells (VSMCs), known as myo-endothelial gap junction (MEGJ), allows direct galvanic and chemical signal exchange between VECs and VSMCs through the inner elasticized layer. VECs pass through MEGJ To achieve its regulation of vascular tone function. Gap junctional exchange is involved in the regulation of vascular hyporeactivity after hemorrhagic shock.