论文部分内容阅读
本文用乌头碱诱发大鼠心律失常的模型研究了常咯啉、心得安及合用后的抗心律失常作用。两药合用后抗室性早搏发生有相加作用,抗室颤发生有增强作用。同时比较合用组和心得安组给药后心得安的血浓度。此两组血浓度无显著性,即两药合用所产生的协同作用不是由于血浆中心得安浓度变化引起的。由此实验说明,对轻度心律失常,两药合用或单用无区别,而对严重心律失常,合用效果显著。但如何合理用于临床有待于探讨。
In this paper, aconitine-induced arrhythmia rat models of the study of the anti-arrhythmic effect of combination of propanidine, propranolol and combination. After the combination of two anti-ventricular premature beats have an additive effect, anti-ventricular fibrillation have an enhanced role. At the same time, we compared the blood concentration of propranolol in the combined group and propofol group. The two groups of blood concentration was not significant, that is, the combination of the two drugs synergistic effect is not due to plasma concentrations of the concentration of safety caused. This experiment shows that, for mild arrhythmia, no difference between the two drugs combined or single, and for serious arrhythmia, combined with significant results. However, how to use it in clinic should be explored.