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目的:考察苍鹅鼻炎片中鱼腥草素钠在水溶液中的稳定性。方法:采用高效液相色谱法,考察时间、温度等因素对水溶液中鱼腥草素钠稳定性的影响情况。结果:苍鹅鼻炎片中的鱼腥草素钠在水溶液中的降解反应为一级动力学模式,片中的鱼腥草素钠在37℃水溶液中t_(0.9)=27.81 min,t_(0.5)=182.85 min;在25℃水溶液中t_(0.9)=58.92 min,t_(0.5)=387.37 min。结论:苍鹅鼻炎片中鱼腥草素钠在水溶液中不稳定,在37℃水溶液中27.81 min下降10%,在182.85 min降解50%。
Objective: To investigate the stability of sodium houttuyfonate in Cang goo rhinitis tablets in aqueous solution. Methods: The effects of time, temperature and other factors on the stability of sodium houttuyfonate in aqueous solution were investigated by high performance liquid chromatography. Results: The degradation reaction of sodium houttuyfonate in Ganshu rhinitis tablet in aqueous solution was first-order kinetic model. The sodium houttuyfonate sodium in the solution at 37 ℃ had t 0.9 = 27.81 min, t 0.5, ) = 182.85 min; t_ (0.9) = 58.92 min, t_ (0.5) = 387.37 min in 25 ℃ aqueous solution. Conclusion: Sodium houttuyfonate in Cang Huo rhinitis tablets is unstable in aqueous solution. The sodium houttuyfonate is decreased by 10% at 27.81 min in 37 ℃ aqueous solution and 50% at 182.85 min.