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为探讨通气障碍性呼吸衰竭时心脏血流动力学的变化,选用健康杂种犬14只,随机分为正常呼吸组(n=5)和呼吸衰竭组(n=9),戊巴比妥钠30mg/kg体重腹腔麻醉下行气管插管。机械通气,监测通气量。开胸暴露心脏,颈总动脉和心尖部插管,以测平均动脉压和左室内压,兼取血样,以动脉血氧分压>70mmHg,氧饱和度>91％,PaCO_2在<30mmHg以及pHa在7.35～7.45作为正常呼吸标准,对照组则降低通气量到60ml/min/kg体重左右,并以PaO_2<60mmHg,PaCO_2>40mmHg作为呼吸衰竭的标准。两组动物均在术后30′测取血气及血流动力学指标作为对照值,以后每隔15′重复记录一次,共观察45′。结果如下:
In order to investigate the changes of cardiac hemodynamics in patients with ventilatory failure, 14 healthy mixed dogs were randomly divided into normal breathing group (n = 5) and respiratory failure group (n = 9), pentobarbital sodium / kg body weight abdominal tracheal intubation anesthesia. Mechanical ventilation, ventilation monitoring. Thoracotomy was performed to expose the heart, common carotid artery and apical part to measure the mean arterial pressure and left ventricular pressure. Blood samples were taken at a partial pressure of arterial oxygen> 70mmHg, oxygen saturation> 91%, PaCO_2 at <30mmHg and pHa In the range of 7.35 ~ 7.45 as normal breathing, the control group decreased the ventilation volume to 60ml / min / kg body weight and used PaO_2 <60mmHg and PaCO_2> 40mmHg as the standard of respiratory failure. Blood gases and hemodynamics were measured at 30 ’postoperatively in both groups as control values, and were repeated every 15’ for a total of 45 ’observation. The result is as follows: