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血管紧张肽原(Angiotensinogen,AGT)是一种血浆糖蛋白,可由肝脏、胎盘、垂体前叶、卵巢、睾丸和脑等器官合成。血浆AGT主要有61.4kDa和65.4kDa两个低分子量亚型。AGT及其降解产物血管紧张素Ⅰ～Ⅳ等,构成内分泌、旁分泌和自分泌激素系统,在肾脏、睾丸、卵巢和脑等靶器官发挥重要功能。为评价AGT基因(Agt)缺陷对啮齿动物生殖力的影响,将具有0个(Agt~(-/-))、1个(Agt~(-/-))、2个(Agt~(+/+))基因拷贝的成年小鼠按下列方式分组交配:A组:Agt~(-/-)×Agt~(-/-),B组:Agt~(-/+)×Agt~(-/+),C组:Agt~(+/+)×Agt~(+/+),D组:
Angiotensinogen (AGT) is a plasma glycoprotein that can be synthesized by the liver, placenta, anterior pituitary, ovary, testis, and brain. Plasma AGT mainly has two low molecular weight subtypes of 61.4kDa and 65.4kDa. AGT and its degradation products angiotensin Ⅰ ~ Ⅳ, constitute the endocrine, paracrine and autocrine hormone system, in the kidney, testis, ovary and brain and other target organs play an important role. To evaluate the effect of AGT gene (Agt) deficiency on rodent fecundity, Agr (Agt ~ (-) -), Agt ~ (- +)) Gene copies of the adult mice were mated in groups as follows: Group A: Agt ~ (- / -) × Agt ~ (- / -), Group B: Agt ~ (- / +) × Agt ~ (- +), C group: Agt ~ (+ / +) × Agt ~ (+ / +), D group: