论文部分内容阅读
本文以糖皮质激素受体拮抗剂ＲＵ４８６为工具药，进一步探讨吗啡急性成瘾模型小鼠的免疫抑制效应及其机制。结果，ＲＵ４８６５，２０ｍｇ／ｋｇ，灌胃给药，ｑｄ×４ｄ，可不同程度地逆转反复吗啡处置对小鼠免疫器官指数、腹腔巨噬细胞吞噬能力、ＣｏｎＡ或ＬＰＳ诱导脾细胞的增殖反应、足跖迟发型超敏反应和空斑形成细胞溶血能力的抑制效应。而ＲＵ４８６对正常小鼠的上述免疫学指征皆无明显影响。本研究证实，肾上腺的激活是吗啡体内给药所致免疫抑制效应的作用机制之一。
In this paper, glucocorticoid receptor antagonist RU486 as a tool to further explore the model of morphine acute addiction in mice immunosuppressive effect and its mechanism. Results, RU4865, 20mg / kg, intragastric administration, qd × 4d, to varying degrees reversal of morphine treatment on mice immune organ index, phagocytic capacity of peritoneal macrophages, ConA or LPS-induced proliferation of splenocytes, Inhibitory effect of delayed metatarsophageal hypersensitivity and hemolysis of plaque-forming cells. While RU486 had no obvious effect on the above immunological indications in normal mice. This study demonstrates that activation of the adrenal gland is one of the mechanisms of immunosuppressive effects induced by morphine administration in vivo.