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目的大肠癌发病率逐年增加,其发病机制未完全明了。自噬在肿瘤的发生、发展中有重要作用,Beclin1(BECN 1)是哺乳动物参与自噬的特异性基因,本研究采用循证医学的方法分析大肠癌组织中Beclin1表达的临床意义,为Beclin1对大肠癌发生、发展的影响提供可靠的证据。方法检索Cochrane library、PubMed、Web of Science、EMBASE、Springer link、中国知网、万方数据库和维普中文科技期刊数据库等至2016-04-01,收集发表的关于大肠癌组织中Beclin1在不同特征人群中表达的文献,筛选符合标准的文献。采用纽卡斯尔-渥太华量表(New castle-Ottawa Scale,NOS)对文献质量进行严格质控,应用RevMan 5.3软件进行数据处理。结果最终纳入15篇文献,包括大肠癌患者1 733例。Meta分析结果显示,大肠癌组织中Beclin1阳性率明显高于大肠腺瘤组织(OR=2.48,95%CI为1.41~4.37,P<0.05)及正常大肠组织(OR=8.33,95%CI为3.92~17.72,P<0.05);腺瘤组织Beclin1阳性率明显高于正常大肠组织,OR=4.49,95%CI为2.29~8.80,P<0.05;管状腺癌组织中Beclin1阳性率略高于除腺癌外其他类型癌组织,OR=0.1,95%CI为0.00~0.19,P=0.04。Beclin1表达与大肠癌患者的年龄、性别、临床分期、发病部位、肿瘤大小、病理类型、是否侵及浆膜及是否转移等无相关性,均P>0.05。结论 Beclin1基因促进了大肠癌的形成与发展。
Objective The incidence of colorectal cancer increased year by year, the pathogenesis is not fully understood. Autophagy plays an important role in tumorigenesis and development. Beclin1 (BECN1) is a mammalian gene involved in autophagy. In this study, the clinical significance of Beclin1 expression in colorectal cancer was analyzed by evidence-based medicine. Beclin1 The occurrence and development of colorectal cancer provide reliable evidence. Methods Cochrane library, PubMed, Web of Science, EMBASE, Springer link, CNKI, Wanfang database and VIP database were searched and searched until 2016-04-01. The data of Beclin1 in colorectal cancer tissues collected from different populations In the expression of the literature, screening of standards-compliant literature. The quality of the literature was tightly controlled using the Newcastle-Ottawa Scale (NOS) and data was processed using RevMan 5.3 software. The results eventually included 15 articles, including 1 733 cases of colorectal cancer. Meta analysis showed that the positive rate of Beclin1 in colorectal cancer was significantly higher than that in colorectal adenoma (OR = 2.48, 95% CI 1.41-4.37, P <0.05) and normal colorectal tissues (OR = 8.33, 95% CI 3.92 ~ 17.72, P <0.05). The positive rate of Beclin1 in adenoma was significantly higher than that in normal colorectal tissue (OR = 4.49, 95% CI 2.29-8.80, P <0.05). The positive rate of Beclin1 in tubular adenocarcinoma was slightly higher than that in adenocarcinoma Other types of cancer outside the cancer, OR = 0.1, 95% CI 0.00 ~ 0.19, P = 0.04. There was no correlation between the expression of Beclin1 and the age, gender, clinical stage, location of tumor, tumor size, pathological type, invasion of serosa and metastasis in patients with colorectal cancer. Conclusion Beclin1 gene promotes the formation and development of colorectal cancer.