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目的:观察逐瘀汤透药对糖尿病周围神经病变患者血清8-异前列腺素F2_α(8-iso-PGF2_α)的影响并评价其疗效。方法:选取糖尿病周围神经病变住院患者60例,随机分为对照组和中医组各30例,对照组患者采用常规降糖治疗,中医组患者采用血府逐瘀汤定向透药治疗,分析比较两组患者治疗前后8-iso-PGF2_α水平的变化。结果:治疗前两组患者的8-iso-PGF2_α比较无统计学差异(P>0.05);治疗后两组患者的血清8-iso-PGF2_α水平都有所下降,且中医组患者明显低于对照组,差异有统计学意义(P<0.05)。结论:逐瘀汤透药治疗可降低糖尿病周围神经病变患者血清8-iso-PGF2_α,改善患者氧化应激,值得临床推广应用。
Objective: To observe the effect of Zhuyu Decoction on the serum 8-iso-PGF2α in patients with diabetic peripheral neuropathy and to evaluate its efficacy. Methods: Sixty hospitalized patients with diabetic peripheral neuropathy were randomly divided into control group (30 cases) and traditional Chinese medicine group (30 cases). Patients in control group were treated with regular hypoglycemic treatment. Patients in Chinese medicine group were treated with Xuefu Zhuyu Decoction The changes of 8-iso-PGF2α level in the patients before and after treatment. Results: There was no significant difference in 8-iso-PGF2α between the two groups before treatment (P> 0.05). The levels of 8-iso-PGF2α in both groups decreased after treatment, and the levels in TCM group were significantly lower than those in control group Group, the difference was statistically significant (P <0.05). Conclusion: Zhuyu Decoction can reduce serum 8-iso-PGF2α in patients with diabetic peripheral neuropathy and improve oxidative stress in patients with diabetic peripheral neuropathy, which is worthy of clinical application.