C35基因是近年来发现的在乳腺癌细胞中特异性高表达,而在正常乳腺上皮细胞中不表达的基因,且C35基因的高度表达较Her2/-neu更为直接,表达谱更为广泛和稳定。C35基因可通过其保守的ITAM结构域促使细胞癌变,已成为一种新的特异性乳腺癌标志基因。本文综述了C35基因的序列分析、表达调控、致癌机制、互作因子和结构研究等方面的研究进展。 C35 gene is a gene that is highly expressed in breast cancer cells in recent years but not expressed in normal mammary epithelial cells. C35 gene is more directly expressed than Her2 / -neu and has a more extensive expression profile stable. C35 gene through its conserved ITAM domain to promote cell carcinogenesis, has become a new specific breast cancer marker gene. This review summarizes the progresses in C35 gene sequence analysis, expression regulation, carcinogenesis, interaction factors and structural studies.