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用高能冲击波治疗由Ｎ－甲基亚硝基脲诱导的大鼠膀胱肿瘤的实验研究，病理和电镜观察显示单次高能冲击波对膀胱肿瘤细胞无影响，连续两次高能冲击波处理后，４８小时起出现肿瘤细胞坏死，随时间延长，肿瘤坏死增加。高能冲击波主要引起肿瘤细胞内线粒体肿胀等改变，从而导致细胞坏死，流式细胞仪检查示高能冲击波必理后Ｓ期细胞数明显下降。结果表明连续两次高能冲击波处理对膀胱肿瘤细胞确实存在直接和间接毒性作用。
High-energy shock wave treatment of N-methylnitrosourea-induced rat bladder tumor experimental study, pathology and electron microscopy showed that a single high-energy shock wave had no effect on bladder tumor cells, two consecutive high-energy shock wave treatment, 48 hours Tumor necrosis appears, with the extension of time, increased tumor necrosis. High-energy shock waves mainly caused changes of mitochondrial swelling in tumor cells, leading to cell necrosis. Flow cytometry showed that the number of S-phase cells in high-energy shock wave decreased significantly. The results show that two consecutive high-energy shock wave treatment of bladder tumor cells do have direct and indirect toxicity.