青霉胺至今仍然是治疗肝豆状核变性(hepatolenticular degeneration,简称HLD)的主要药物。近年来对锌剂治疗HLD的研究有所增多,本文就该病用青霉胺及锌剂治疗的疗效进行比较,以探讨合理治疗方法。 临床资料和方法 1.治疗分组 青霉胺治疗组与锌剂治疗组病人计69例,其中11例为家族成员普查中发现的症状前患者,即无神经症状及肝机能损害症状,但血清铜蓝蛋白降低,角膜 Penicillium is still the main drug for the treatment of hepatolenticular degeneration (HLD). In recent years, the study of zinc treatment of HLD has increased, this article on penicillin and zinc treatment of efficacy compared to explore the reasonable treatment. Clinical data and methods 1. Treatment group Penicillamine treatment group and zinc treatment group of patients, 69 cases, of which 11 cases were found in the family member survey before the symptoms, that is, no neurological symptoms and symptoms of liver damage, but serum copper Blue protein decreased corneal