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应用流式细胞术和细胞免疫荧光染色技术,对胃癌前病变和胃癌细胞P21 ̄(ras)的表达量进行了定量研究,并分析了P21 ̄(ras)的表达量与DNA倍体和细胞增殖指数的关系。结果表明:胃癌细胞P21 ̄(ras)表达量(荧光指数FI)明显高于胃癌前病变的表达量,并发现P21 ̄(ras)表达的荧光指数随组织学分级增高而升高,DNA倍体与P21 ̄(ras)表达量有密切关系。
The expression of P21 ̄ (ras) in gastric precancerous lesions and gastric cancer cells was quantitatively studied by flow cytometry and immunofluorescence staining, and the expression of P21 ̄ (ras) and DNA ploidy and cell proliferation were analyzed. The relationship of the index. The results showed that the expression of P21 ̄ (ras) in gastric cancer cells was significantly higher than that in precancerous lesions, and the fluorescence index of P21 ̄ (ras) expression was increased with histological grading, and DNA ploidy was found. It is closely related to the expression of P21 ~ (ras).