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目的探讨拉莫三嗪在丙戊酸治疗无效的癫痫患者中的应用价值。方法运用随机抽样的方法选取本院2013年1月—2014年9月收治的80例丙戊酸治疗无效的癫痫患者,依据随机数字表法将这些患者分为研究组和对照组各40。对照组患者给予单纯拉莫三嗪治疗,研究组给予患者拉莫三嗪联合丙戊酸治疗,然后对两组患者的临床疗效、拉莫三嗪血药浓度及不良反应发生情况进行统计分析。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果研究组患者治疗的总有效率90.0%(36/40)显著高于对照组70.0%(28/40),差异有统计学意义(P<0.05);拉莫三嗪血药浓度(8.61±2.93)μg/ml显著高于对照组(3.81±1.17)μg/ml,差异有统计学意义(P<0.05);不良反应发生率20.0%(8/40)显著低于对照组45.0%(18/40),差异有统计学意义(P<0.05)。结论拉莫三嗪在丙戊酸治疗无效的癫痫患者中具有较高的应用价值,值得推广。
Objective To investigate the value of lamotrigine in the treatment of patients with epilepsy induced by valproic acid. Methods Eighty patients with valproic acid ineffective epilepsy treated in our hospital from January 2013 to September 2014 were selected by random sampling. The patients were divided into study group and control group according to random number table method. Patients in the control group were treated with lamotrigine alone. Patients in the study group were treated with lamotrigine plus valproic acid, and then the clinical efficacy, lamotrigine plasma concentration and incidence of adverse reactions in both groups were statistically analyzed. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of study group was 90.0% (36/40), which was significantly higher than that of the control group (70.0%, 28/40) (P <0.05). The lamotrigine plasma concentration (8.61 ± 2.93) μg / ml was significantly higher than that of the control group (3.81 ± 1.17) μg / ml, the difference was statistically significant (P <0.05); adverse reaction rate was 20.0% (8/40) / 40), the difference was statistically significant (P <0.05). Conclusions Lamotrigine is of high value in the treatment of patients with epilepsy with valproic acid deficiency and is worthy of promotion.