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用碱洗脱荧光分析法检测两种萘胺对DNA交联性损伤的研究结果表明,浓度在7.1～14.3μg/ml时1-萘胺未造成DNA的横向交联性损伤,而2-萘胺却引起这种类型的损伤,并呈现剂量效应关系。在细胞转化试验中,浓度在1.8～14.3μg/m时,1-萘胺为阴性结果,2-萘胺为阳性结果。
The results of alkali-eluting fluorescence assay for DNA cross-linking damage of two naphthylamines showed that 1-naphthylamine did not cause transverse cross-linking damage at the concentration of 7.1 ~ 14.3μg / ml, while 2-naphthalene Amines cause this type of injury and show a dose-response relationship. In the cell transformation assay, 1-naphthylamine was negative and the 2-naphthylamine was positive at concentrations of 1.8 to 14.3 μg / m.