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目的:研究黄连解毒汤(由黄连、黄芩、黄柏、栀子等4味中药组成的复方)的化学成分,为其药代动力学和药效动力学研究提供物质基础。方法:采用各种柱色谱方法进行分离、纯化,NMR和MS等方法进行结构鉴定。结果:从黄连解毒汤的醋酸乙酯可溶性部分得到1个新的黄酮苷,命名为汉黄芩素-5-O-β-D-葡萄糖醛酸苷甲酯(wogonin-5-O-β-D-glucuronidemethyl ester,1)。从正丁醇可溶性部分得到10个化合物,分别鉴定为小檗碱(2),巴马汀(3),表小檗碱(4),京尼平苷(5),药根碱(6),非洲防己碱(7),格陵兰黄连碱(8),汉黄芩苷(9),3,5-二乙酰胺吡啶(10)和京尼平-1-O-β-D-龙胆双糖苷(11)。结论:化合物1为新化合物。根据已报道4味中药化学成分的研究结果,判断化合物2,3和6来源于黄柏和黄连;化合物4,7和8来源于黄连;化合物5和11来源于栀子;2个黄酮苷来源于黄芩。
OBJECTIVE: To study the chemical constituents of Huanglian Jiedu Decoction (a compound prescription made up of 4 herbs of Coptis, Scutellaria, Cortex Phellodendri, Gardenia jasminoides) for its pharmacokinetics and pharmacodynamics. Methods: Various column chromatography methods were used for the identification of structures, such as isolation, purification, NMR and MS. Results: One new flavonoid glycoside was obtained from the soluble part of the ethyl acetate extract of Huanglian Jiedu Decoction, and named as wogonin-5-O-β-D -glucuronidemethyl ester, 1). Ten compounds were obtained from the soluble fraction of n-butanol and identified as berberine (2), palmatine (3), epiberberine (4), geniposide (5) (8), baicalin (9), 3,5-diacetamide pyridine (10) and genipin-1-O-β-D-gentiobioside (11). Conclusion: Compound 1 is a new compound. According to the reported results of the chemical constituents of 4 Chinese herbs, it is concluded that compounds 2, 3 and 6 are derived from Phellodendron and Coptis; compounds 4, 7 and 8 are derived from Coptis; compounds 5 and 11 are derived from Gardenia jasminoides; 2 flavonoids are derived from Scutellariae.