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目的:分析对瘢痕子宫中期妊娠采用米非司酮联合依沙吖啶引产的安全性以及有效性。方法:选取广东同江医院收治的50例自愿进行妊娠终止的瘢痕子宫患者,所有入选患者均为中期妊娠,按照随机对照原则将患者分为观察组和对照组。对照组患者采用单纯依沙吖啶引产,观察组患者采用依沙吖啶联合米非司酮引产。对两组患者引产情况、引产效果、引产不良反应等方面进行评估。结果:观察组宫缩开始时间、引产总时间、出血量、住院时间等明显低于对照组(P<0.05),观察组患者引产成功率100.0%,对照组引产成功率为84.0%,观察组引产成功率明显高于对照组(P<0.05),而且观察组患者中胎盘胎膜残留、胎盘粘连、软产道损伤等发生情况低于对照组(P<0.05)。两组患者不良反应发生情况对比(P>0.05)。结论:依沙吖啶联合米非司酮对中期妊娠的瘢痕子宫进行引产是安全有效的,能够明显加快患者宫缩的产生,减少引产时间,减少引产出血量,降低相关并发症的发生。
OBJECTIVE: To analyze the safety and efficacy of mifepristone combined with ethacridine induction in the treatment of scar pregnancy. Methods: Fifty patients with scar uterus who volunteered for termination of pregnancy were enrolled in Guangdong Tongjiang Hospital. All the patients were enrolled in the second trimester pregnancy. According to the randomized control principle, the patients were divided into observation group and control group. Patients in the control group were treated with ethacridine alone, while those in the observation group were given ethacridine plus mifepristone. Induction of labor in two groups of patients, induction of labor, induction of adverse reactions and other aspects of assessment. Results: The onset time of contractions, the total time of labor, the amount of bleeding and the length of hospital stay in the observation group were significantly lower than those in the control group (P <0.05). The success rate of induction of labor in the observation group was 100.0% and that of the control group was 84.0% The successful rate of induction of labor was significantly higher than that of the control group (P <0.05). The occurrence of placental residual membrane, placental adhesion and soft birth canal injury in the observation group was lower than that in the control group (P <0.05). Adverse reactions between the two groups were compared (P> 0.05). Conclusion: Ethacridine combined with mifepristone is safe and effective in inducing abortion of uterine scar in the second trimester pregnancy. It can significantly speed up the production of uterine contractions, reduce the time of induction of labor, reduce the amount of induced labor and reduce the incidence of related complications.