Pilot biomechanical design of biomaterials for artificial nucleus prosthesis was carried out based on the 3D finite-element method. Two 3D models of lumbar intervertebral disc respectively with a real human nucleus and with the nucleus removed were developed and validated using published experimental and clinical data. Then the models with a stainless steel nucleus prosthesis implanted and with polymer nucleus prostheses of various properties implanted were used for the 3D finite-element biomechanical analysis. All the above simulation and analysis were carried out for the L4/L5 disc under a human worst-daily compression load of 2000 N. The results show that the polymer materials with Young’s modulus of elasticity E = 0.1-100 MPa and Poisson’s ratio v= 0.35-0.5 are suitable to produce artificial nucleus prosthesis in view of biomechanical consideration. Pilot biomechanical design of biomaterials for artificial nucleus prost was was out based on the 3D finite-element method. Two 3D models of lumbar intervertebral disc respectively with a human nucleus and with the nucleus removed were developed and validated using published experimental and clinical data. Then the models with a stainless steel nucleus prosthesis implanted and with polymer nucleus prostheses of various properties implanted were used for the 3D finite-element biomechanical analysis. All the above simulation and analysis were carried out for the L4 / L5 disc under a human worst- daily compression load of 2000 N. The results show that the polymer materials with Young’s modulus of elasticity E = 0.1-100 MPa and Poisson’s ratio v = 0.35-0.5 are suitable to produce artificial nucleus prosthesis in view of biomechanical considerations.