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冠心病是严重危害人类健康的疾病之一,其病理基础为冠状动脉硬化及斑块形成,炎症机制在AS斑块的发生发展过程中起重要作用〔1〕。同时,冠心病又是一个多因素导致的疾病,目前发现多种基因多态性与冠心病易感有关。单核细胞趋化蛋白1(Mcp-1)是参与AS斑块形成发生发展过程的重要物
Coronary heart disease is one of the diseases that seriously endanger human health. Its pathological basis is coronary atherosclerosis and plaque formation. Inflammatory mechanism plays an important role in the development of AS plaque [1]. At the same time, coronary heart disease is a multi-factorial disease, found that a variety of genetic polymorphisms and coronary heart disease susceptibility. Monocyte chemotactic protein 1 (Mcp-1) is involved in the development of AS plaque formation and development of important things