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目的 探讨非嗜肝病毒所致肝炎的病因和临床特征。 方法 对68例非甲-非戊型肝炎患者进行临床研究,用常规方法检测甲-戊型肝炎的标志物,排除嗜肝病毒感染。再检测单纯疱疹病毒、EB病毒、巨细胞病毒、柯萨奇病毒IgM、IgG型抗体和自身抗体(线粒体抗体和抗核抗体),随访6个月,并将其临床症状和体征与同期嗜肝病毒所致急性肝炎比较。 结果 68例非嗜肝病毒所致肝炎中单纯疱疹病毒感染9例,EB病毒感染12例,巨细胞病毒感染8例,柯萨奇病毒感染14例,线粒体抗体和抗核抗体阳性的13例,不明原因者12例。排除13例线粒体抗体和抗核抗体阳性患者和12例不明原因患者后,43例由非嗜肝病毒感染所致肝炎患者中35例发生在冬春季节,其临床症状似较嗜肝病毒所致急性肝炎轻。 结论 单纯疱疹病毒、EB病毒、巨细胞病毒、柯萨奇病毒感染可以肝脏损害为突出表现,临床表现为急性肝炎,有一定的季节性,其临床症状较轻。
Objective To investigate the etiology and clinical features of hepatitis caused by non-hepadnavirus. Methods A total of 68 patients with non-A and non-E hepatitis were enrolled in the study. A-hepatitis E markers were detected by routine methods and the infection of hepadnavirus was excluded. The herpes simplex virus, Epstein-Barr virus, cytomegalovirus, Coxsackie virus IgM, IgG type antibody and autoantibodies (mitochondrial antibody and antinuclear antibody) were tested again for 6 months, and their clinical symptoms and signs were compared with those of the same period Virus-induced acute hepatitis comparison. Results In 68 cases of non-hepadnavirus-induced hepatitis, 9 were herpes simplex virus, 12 were Epstein-Barr virus, 8 were cytomegalovirus, 14 were Coxsackie virus, 13 were mitochondrial and antinuclear antibodies, 12 cases of unknown reason. Excluding 13 mitochondrial and antinuclear antibody-positive patients and 12 patients with unexplained causes, 35 of 43 patients with hepatitis caused by non-hepadnavirus infection occurred in winter and spring, and their clinical symptoms appeared to be more likely than those of hepadnavirus Acute hepatitis is light. Conclusions Herpes simplex virus, Epstein-Barr virus, cytomegalovirus and Coxsackie virus infection can highlight liver damage. The clinical manifestations are acute hepatitis, with a certain seasonal and mild clinical symptoms.