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目的研究泰山产天目琼花Viburnum sargentii枝叶的化学成分。方法利用硅胶柱色谱、凝胶Sephadex LH-20柱色谱,中压反相硅胶柱色谱以及高效液相色谱等各种现代色谱方法进行分离纯化;通过ESI-MS、1D-NMR、2D-NMR等现代波谱技术,并与文献数据对照鉴定化合物的结构。结果从天目琼花枝叶95%乙醇提取物中分离鉴定了13个化合物,包括7个三萜类化合物:α-香树脂醇(1)、熊果醇(2)、3α-乌苏酸(3)、11,12-去氢熊果酸内酯(4)、3-乙酰基齐墩果醛(5)、齐墩果酸(6)、白桦脂酸(7);5个木脂素类化合物:木兰脂素(8)、(+)-桉脂素(9)、(-)-表桉叶明(10)、vibsanol(11)、3,4′-dimethoxylvibsanol(12);1个苯丙素类化合物:α-细辛醚(13)。结论化合物12是1个新的天然产物,化合物1~11和13均为首次从天目琼花植物中分离得到。
Objective To study the chemical constituents of Viburnum sargentii in Taishan Mountain. Methods The compounds were separated and purified by using various modern chromatographic methods, such as silica gel column chromatography, gel Sephadex LH-20 column chromatography, medium-pressure reverse phase silica gel column chromatography and high performance liquid chromatography. By ESI-MS, 1D-NMR, 2D- Modern spectroscopic techniques, and the literature data to identify the structure of compounds. Results Thirteen compounds, including triterpenoids, were isolated and identified from 95% ethanol extract of Vicia faba. The compounds included α-amyrin (1), arbutin (2), and 3α-ursolic acid ), 11,12-dehydroabierolactone (4), 3-acetyl oleanalic acid (5), oleanolic acid (6), betulinic acid (7) Compounds: Magnolins (8), (+) - Eucalyptol (9), (-) - Table Eucalyptus (10), vibsanol (11), 3,4’-dimethoxylvibsanol Propanoids: α-asarone (13). Conclusion Compound 12 is a new natural product. Compounds 1-11 and 13 were isolated from the plants of Viburnum for the first time.