在9例病人中进行安替比林(A)试验及甲氰咪胍(C)+苯妥英(P)交互作用的研究,另2例因副作用中止试验而除外。实验设计:一、口服 A 的试验:第一次在 P 开始治疗前,第二次在 P 应用2～4月后,第三次是 P+C 合用20天后进行。剂量为10mg/kg 溶于水,清晨空腹时吞服。于服后2,4,6,8及24时采取血样。二、交互作用的研究:P 的剂量为每天200～300mg,分2次(7及22时)服。连服2个月后,给予 C。C 每天剂量为1000mg Antipyrine (A) and cimetidine (P) interactions were studied in nine patients, with the other two being discontinued due to side effects discontinuation. Experimental design: First, the oral A test: the first time before P treatment, the second application of P 2 to 4 months, the third is the P + C combined with 20 days. Dose of 10mg / kg dissolved in water, swallowed fasting morning. Blood samples were taken at 2, 4, 6, 8 and 24 hours post-service. Second, the interaction of the study: P dose of 200 ~ 300mg daily, divided into 2 times (7 and 22 o’clock) service. After serving 2 months, give C. C daily dose of 1000mg