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目的评价厄贝沙坦联合小剂量吲哒帕胺治疗70岁以上老年人高血压的疗效。方法60例70岁以上老年人轻中度高血压随机分为治疗组:晨服厄贝沙坦150mg,1次/d,联合应用吲哒帕胺1.25mg,1次/d;对照组:晨服厄贝沙坦150mg,1次/d;两组疗程均为8W。治疗前、后监测血压、血糖、血脂、血尿酸、肝肾功能和血钾。结果两组治疗前、后对代谢无明显影响,治疗组降压效果更显著(P<0.01)。结论厄贝沙坦联合小剂量吲哒帕胺治疗70岁以上老年人轻中度高血压安全有效,可作为老年人降压治疗的一线用药。
Objective To evaluate the efficacy of irbesartan combined with low-dose indapamide in the treatment of hypertension in the elderly over 70 years old. Methods Sixty elderly patients over 70 years old with mild to moderate hypertension were randomly divided into treatment group: morning service irbesartan 150mg, 1 time / d, combined with indapamide 1.25mg, 1 / d; control group: morning Irbesartan 150mg, 1 / d; two courses of treatment were 8W. Before and after treatment, blood pressure, blood glucose, blood lipids, blood uric acid, liver and kidney function and serum potassium were monitored. Results The two groups had no significant effect on metabolism before and after treatment, and the antihypertensive effect was more significant in the treatment group (P <0.01). Conclusion Irbesartan combined with low-dose indapamide is safe and effective in the treatment of mild-moderate hypertension in the elderly over 70 years old. It can be taken as the first-line medication for antihypertensive treatment in the elderly.