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米非司酮配伍米索前列醇药物口服终止早期妊娠是目前广泛应用于临床的一种药物流产方法,由于痛苦小、简便、无侵入性伤害,受到众多非意愿妊娠者的青睐。但其可能引起流产后出血量过多、出血时间过长,甚至会发生突然大出血的危险。为了更好的治疗该疾病,现对近年来中西医治疗药物流产后出血的各种治疗方法做一综述。1药物流产的机制:米非司酮为竞争性孕激素受体拮抗剂,与孕酮受体(PR)的结合力比孕酮强3~5倍,即有较强的抗孕激素作用。米非司酮与孕激素受体竞争性结合,阻断孕激素的作用,导致蜕膜及绒毛变性出血坏死,胚胎发育停止。米索前列醇具有收缩子宫和软化宫颈的作用,联合应用两者可促使胚胎排出使流产完全。
Oral administration of mifepristone and misoprostol for early termination of pregnancy is a medical abortion method widely used in clinical practice. It is favored by many unwanted pregnancies because of its small pain, simplicity and non-invasiveness. But it may cause excessive bleeding after abortion, bleeding time is too long, and even the risk of sudden bleeding. In order to better treat the disease, we have reviewed the various treatment methods for the treatment of postpartum hemorrhage by Chinese and Western medicine in recent years. 1 mechanism of medical abortion: mifepristone is a competitive progesterone receptor antagonist, and progesterone receptor (PR) binding progesterone 3 to 5 times stronger, that is, a strong anti-progesterone effect. Mifepristone and progesterone receptor competitive binding, blocking the role of progesterone, resulting in decidual and villous degeneration and hemorrhagic necrosis, embryonic development stopped. Misoprostol has the effect of contracting the uterus and softening the cervix, and the combination of both may cause the embryo to be excreted to completely abort.