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目的：研究双氯芬酸钠在凝胶贮库中的扩散特征及其对双氯芬酸钠透皮扩散速率的影响。方法：以改良的 Ｆｒａｎｚ 扩散池为实验装置，回归分析双氯芬酸钠在二种凝胶基质、共十二种条件下经微孔滤膜或透过离体小鼠皮的累积透过量。结果：在亲水的高分子凝胶基质中，离子形式的双氯芬酸钠扩散速率大于分子形成的扩散速率。经皮扩散时，分子形式的双氯芬酸钠在海藻酸凝胶中的扩散速率大于离子形式的扩散速率；在卡波普凝胶中结果则相反。双氯芬酸钠从含有月桂氮苷卓酮的凝胶中透皮扩散的速率比从相应没有月桂氮苷卓酮的凝胶中透皮扩散的速率有所增加，但增加的程度不明显。特别是当卡波凝胶中是离子形式的双氯芬酸钠时，其有无促透剂的２４ ｈ 累积透过量之比值只为１ ．１７ 。
Objective: To study the diffusion characteristics of diclofenac sodium in gel depots and its effect on the diffusion rate of diclofenac sodium. Methods: A modified Franz diffusion cell was used as the experimental device. The cumulative permeation rates of diclofenac sodium in two kinds of gel matrix, a total of twelve conditions through the microporous membrane or through the ex vivo mouse skin were analyzed. Results: In the hydrophilic polymeric gel matrix, the diffusion rate of diclofenac sodium in ionic form is greater than the diffusion rate of molecular formation. At the time of percutaneous diffusion, the diffusion rate of diclofenac sodium in the molecular form in the alginate gel is larger than that in the ionic form; in Carbopol gel the opposite is true. The rate at which diclofenac sodium transdermally diffused from the gel containing laurocarnate increased compared to the rate of transdermal diffusion from the corresponding gel without laurocapram so that the degree of increase was insignificant. In particular, when the diclofenac sodium in the form of ionic form is present in the cambogia gel, the ratio of cumulative permeation of 24 h with and without permeation enhancer is only one. 17.