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血中氧分压降低和CO_2分压改变与肺动脉高压的关系在临床阻塞性呼吸系统疾患及高原适应不全症中均占有十分重要的地位。研究这一关系有助于探讨这些疾病伴发肺动脉高压的机理,并为其防治提供参考。自40年前Von Euler等观察到吸入气中氧浓度降低和/或CO_2浓度增加均可使猫肺动脉压升高以来的几十年,不少研究者虽就低氧和CO_2对肺动脉压的影响在整体动物、动物离体灌流肺、慢性阻塞性肺疾患病人和正常人体都进行过许多研究。然而,迄今为止,CO_2对肺动脉压的影响尚未取得一致意见。因此,本实验拟在这方西进行探讨,观察吸入不同浓度CO_2对家兔急性低氧性肺动脉升压反应的影响。
Reduced blood oxygen partial pressure and CO 2 partial pressure changes and pulmonary hypertension in the clinical obstructive respiratory disease and altitude sickness are occupying a very important position. Studying this relationship will help to explore the mechanism of these diseases associated with pulmonary hypertension and provide a reference for their prevention and treatment. Since Von Euler et al observed the decrease of oxygen concentration in inhaled gas and / or the increase of CO 2 concentration 40 years ago, it has been several decades since Von Euler et al. Increased the pulmonary arterial pressure in cats. Although many researchers have studied the effects of hypoxia and CO 2 on pulmonary arterial pressure Many studies have been conducted on whole animals, isolated perfused lungs of animals, patients with chronic obstructive pulmonary disease and normal humans. However, until now, no agreement has been reached on the effect of CO 2 on pulmonary arterial pressure. Therefore, this experiment is intended to explore in this side of the West to observe the effects of inhaled different concentrations of CO 2 on acute hypoxic pulmonary hypertension in rabbits.