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目的探讨T2DM患者二甲双胍治疗后血清同型半胱氨酸(Hcy)、维生素B_(12)(Vit B_(12))、叶酸(FA)水平的变化。方法 44例T2DM患者在原治疗的基础上口服二甲双胍,治疗前和治疗半年后测定血清Hcy、Vit B_(12)、FA水平。结果口服二甲双胍半年后,血清Vit B_(12)、FA水平下降,Hcy水平升高,其升高与二甲双胍使用剂量、Vit B_(12)、FA下降相关。结论二甲双胍口服半年可降低T2DM患者Vit B_(12)、FA水平,升高血清Hcy水平。
Objective To investigate the changes of serum homocysteine (Hcy), vitamin B 12 (Vit B 12) and folic acid (FA) in patients with T2DM after metformin treatment. Methods Forty - four patients with T2DM were treated with metformin orally, and serum Hcy, Vit B 12 and FA levels were measured before treatment and six months after treatment. Results After six months of oral administration of metformin, the levels of serum Vit B 12 and FA decreased and the level of Hcy increased. The increased dose of metformin was associated with the decreased dose of metformin and Vit B 12 and FA. Conclusions Metformin can reduce Vit B 12 and FA levels and increase serum Hcy levels in patients with T2DM six months after oral administration.