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目的研究对氧磷酯酶1(PON1)活性测定在慢性肝病中的意义。方法分别对肝硬化组、慢性肝炎组及正常对照组的血清标本进行PON1活性及其他生化指标测定,比较不同组之间的差异。结果血清PON1活性在慢性肝炎组及肝硬化组显著降低(P<0.05)。在慢性肝病中,PON1活性的降低与其他生化指标之间存在一定的相关关系。血清PON1的受试者工作特性曲线(ROC曲线)分析可知,慢性肝炎中与ALT有相似的曲线下面积(AUC),而肝硬化组中则PON1活性的AUC为最高。结论血清PON1活性的测定在慢性肝病中有着重要的意义,对区分慢性肝炎及肝硬化也有一定的作用。
Objective To study the significance of measuring the activity of paraoxonase 1 (PON1) in chronic liver disease. Methods Serum samples from patients with cirrhosis, chronic hepatitis and normal controls were assayed for PON1 activity and other biochemical parameters, and the differences between different groups were compared. Results Serum PON1 activity was significantly decreased in chronic hepatitis group and cirrhosis group (P <0.05). In chronic liver disease, the decrease of PON1 activity has certain correlation with other biochemical indexes. The receiver operating characteristic curve (ROC curve) analysis of serum PON1 shows that the area under the curve (AUC) is similar to ALT in chronic hepatitis, while the AUC of PON1 activity in cirrhosis group is the highest. Conclusions The determination of serum PON1 activity is of great significance in the treatment of chronic liver diseases and also plays a role in differentiating chronic hepatitis from cirrhosis.