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目的检测PI3K/Akt/m TOR信号传导通路传导分子PI3K、Akt、m TOR下游信号分子磷酸化情况,评估该通道活化情况,探讨套细胞淋巴瘤(MCL)发病机制。方法选择医院病理科2005~2015年MCL石蜡包埋标本15例(MCL组)和淋巴结反应性增生(LRH)20例(LRH组)。应用免疫组织化学技术检测2组p-Akt、p-m TOR、p-RPS6的表达水平。结果 MCL组p-Akt、p-m TOR、p-RPS6的阳性表达率均高于LRH组,差异均有统计学意义(P<0.05)。结论 PI3K/Akt/m TOR信号通路在MCL中异常活化,该通路异常表达可能与MCL的发病机制有关。
Objective To detect the phosphorylation of PI3K, Akt and m TOR downstream signaling molecules in PI3K / Akt / m TOR signaling pathway and evaluate the activation of this pathway to explore the pathogenesis of mantle cell lymphoma (MCL). Methods Totally 15 cases of MCL group and 20 cases of reactive lymph node reaction (LRH) were selected from hospitalized department of pathology from 2005 to 2015. Immunohistochemistry was used to detect the expression of p-Akt, p-m TOR and p-RPS6 in two groups. Results The positive rates of p-Akt, p-m TOR and p-RPS6 in MCL group were significantly higher than those in LRH group (P <0.05). Conclusion PI3K / Akt / m TOR signaling pathway is abnormally activated in MCL. The abnormal expression of this pathway may be related to the pathogenesis of MCL.