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目的:了解V1导联终末电势(PTFV1)变化与急性心肌梗死(PTFV1)部位关系,溶栓对其影响及PTFV1异常与住院死亡率关系。方法:将108例AMI病人分为溶栓组35例，非溶栓组73例。108例中，根据不同梗死部位分为广泛前壁15例,前壁39例,前间部14例,下壁40例。测量入院当天及第二天PTFV1并进行分析。结果：入院当天PTFV1异常检出率广泛前壁、前壁、前间壁、下壁分别为100%、74．4%、71．4%、40%，4组间比较有显著性差异（P<0．05)；溶栓组第二天PTFV1异常检出率与入院时比有非常显著性差异（P<0．005)，而非溶栓组无显著差异（P>0．9)。PTFV1明显异常组住院死亡率与轻度异常组及正常组比较有显著性差异（分别P<0．025、P<0．05)。结论：PTFV1异常与心肌梗死部位有关，溶栓使PTFV1负值减小，改善左心功能，PTFV1值与住院死亡率有关。
OBJECTIVE: To investigate the relationship between the changes of terminal lead potential (PTFV1) in V1 lead and the location of acute myocardial infarction (PTFV1), the effect of thrombolysis on PTFV1 and the association between PTFV1 abnormality and in-hospital mortality. Methods: A total of 108 patients with AMI were divided into thrombolysis group (35 cases) and non thrombolysis group (73 cases). 108 cases, according to different infarct sites is divided into a wide anterior wall in 15 cases, anterior wall in 39 cases, anterior chamber in 14 cases, 40 cases of the inferior wall. PTFV1 was measured on the day of admission and on the next day and analyzed. Results: There were significant differences in the detection rate of PTFV1 on the day of admission (anterior, anterior, anterior and inferior wall were 100%, 74.4%, 71.4% and 40%, respectively) (P < 0.05). The detection rate of PTFV1 abnormality in the thrombolytic group was significantly different from that at admission (P <0.005), but no significant difference was found between the two groups (P> 0.9). In-hospital mortality was significantly different between the PTFV1 group and the mild abnormal group (P <0.025, P <0.05, respectively). Conclusion: The abnormality of PTFV1 is related to the location of myocardial infarction. Thrombolytic therapy decreases the negative value of PTFV1 and improves left ventricular function. The value of PTFV1 is associated with hospital mortality.