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目的:观察β七叶皂甙钠预防术后肠粘连作用及对切口愈合的影响。方法:选用Wistar 大鼠40 只,分别刮伤盲肠浆膜,创面滴无水酒精,短暂钳夹盲肠系膜动脉,术后随机分成2 组,分别静脉注射生理盐水和β七叶皂甙钠。术后第7 d 进行大体粘连程度分级,并分别测定盲肠壁及腹壁切口组织的羟脯氨酸(OHP)水平。结果:与对照组相比,β七叶皂甙钠能明显减轻术后肠粘连程度和盲肠壁OHP水平( P<0 .01),而不影响腹壁切口OHP水平( P>0.05)。结论:β七叶皂甙钠能有效预防术后肠粘连。
OBJECTIVE: To observe the effect of β-aescinate on postoperative intestinal adhesion and wound healing. METHODS: Forty Wistar rats were used to scratch the cecal serosa and the wounds were dribbled with absolute alcohol. The cecal mesenteric artery was clamped briefly. The patients were randomly divided into two groups and received intravenous saline and β-aescin sodium. The degree of gross adhesion was graded on the 7th day after operation, and the hydroxyproline (OHP) level in the cecum wall and abdominal wall incision tissue was measured. RESULTS: Compared with the control group, β-aescinate significantly reduced postoperative intestinal adhesion and cecal wall OHP levels (P<0.01) without affecting the abdominal incision OHP level (P>0.05). Conclusion: β-aescinate can effectively prevent postoperative intestinal adhesion.