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目的:分析阴道微生态指标在复发性外阴阴道假丝酵母菌病(RVVC)治疗中的应用价值。方法:随机选取2012年6月~2014年1月本院妇科门诊收治的RVVC患者100例,按照完全抽样法1∶1分成2组,对照组患者在临床治愈后即停止治疗,研究组患者在微生态彻底恢复后停止治疗,比较2组患者临床症状改善与疗效性指标情况、微生态指标恢复正常所需疗程。结果:研究组患者停药后的复发次数[(0.87±0.33)次]比对照组[(3.76±0.49)次]少,总疗程[(7.85±1.23)个]比对照组[(4.16±0.78)个]多,组间比较差异有统计学意义(P<0.01);研究组患者停药后1、2、3个月的复发率均比对照组低,研究组治疗1~5个疗程时的密集度Ⅱ~Ⅲ级比例均比H2O2≥2μmol/L与p H值<4.5比例低,两组间比较差异有统计学意义(P<0.01)。结论:RVCC患者治疗期间动态监测阴道微生态指标,将其作为临床治愈标准,可显著降低患者远期复发风险,具有较高的临床有效性与可行性。
Objective: To analyze the value of vaginal microecology in the treatment of recurrent vulvovaginal candidiasis (RVVC). Methods: 100 patients with RVVC admitted to Gynecology Clinic in our hospital from June 2012 to January 2014 were randomly selected and divided into two groups according to 1: 1 of complete sampling method. Patients in control group were stopped treatment after clinical cure. Patients in study group were treated with After the complete restoration of micro-ecology, the treatment was stopped. The improvement of clinical symptoms and curative effect indexes were compared between the two groups. The courses of microecological indexes returned to normal were compared. Results: The number of patients relapsed in the study group was significantly lower than that in the control group [(0.87 ± 0.33) times [(3.76 ± 0.49) times [(7.85 ± 1.23) (P <0.01). The recurrence rate of the study group was lower than that of the control group at 1, 2 and 3 months after treatment, and the study group treated with 1 to 5 courses of treatment (P <0.01). There was a significant difference between the two groups (P <0.01). Conclusion: The dynamic monitoring of vaginal microecological indicators during treatment in RVCC patients as a clinical cure criterion can significantly reduce the risk of long-term recurrence in patients with high clinical efficacy and feasibility.