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本文报告7例儿童,年龄在1～5岁,应用抗组织胺-巴比妥盐复合栓剂(戊巴比妥-吡拉明栓剂)控制恶心呕吐,其中3例按规定剂量,而另4例则超过规定量。用药后1天内,7例儿童均发生以意识障碍,兴奋性增加以及共济失调为特征的中毒性脑病。这种中毒性脑病是由于药物副作用引起的。许多止吐药都有一定副作用:如酚噻嗪类可引起锥体外系统反应,巴比土类可引起特异性兴奋,包括兴奋、不安,严重者谵妄抗组织胺药可引起失眠、幻觉、兴奋、共济失调、瞳孔扩大、震颤和惊厥。西药联合应用或剂量过大,副作用更加明显。此种脑病病程短暂,经过一般静脉补液后,均能于48小时内恢复。
This article reports seven children, aged 1 to 5 years old, the application of antihistamine-barbiturate salt combination suppository (pentobarbital - piraemide suppository) to control nausea and vomiting, of which 3 were prescribed dose, and the other 4 cases Exceeds the specified amount. Within one day after treatment, all 7 children developed toxic encephalopathy characterized by disturbance of consciousness, increased excitability and ataxia. This toxic encephalopathy is caused by side effects of drugs. Many antiemetic drugs have some side effects: such as phenothiazine can cause extrapyramidal systemic response, barbiturates can cause specific excitement, including excitement, anxiety, severe delirium antihistamine can cause insomnia, hallucinations, excitement , Ataxia, dilated pupils, tremor and convulsions. Combined application of western medicine or overdose, more obvious side effects. This short course of encephalopathy, after general intravenous rehydration, can recover within 48 hours.