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目的 观察肾血管性高血压大鼠（ＲＨＲ）耳郭微血管反应性变化及依那普利的影响。方法 用冷热刺激诱发微血管收缩与舒张，分别用血流量变化幅度和时相评价血管舒缩能力及微血管顺应性。结果 ＲＨＲ血压升高的同时，微血管对热刺激的反应性明显降低，对冷刺激的反应性升高，去除刺激后血流由最大变化恢复至正常的时间延迟，伴血清血管紧张素转化酶（ＡＣＥ）活性升高和硝酸盐／亚硝酸盐（ＮＯ）水平降低。依那普利可有效改善上述变化。结论 ＲＨＲ微血管对舒缩刺激的反应性异常；依那普利具有良好的改善微血管反应性作用，其机制与维护内皮功能的完整性有关。
Objective To observe the changes of auricular microvessel reactivity in renovascular hypertensive rats (RHR) and the effect of enalapril. Methods The contraction and relaxation of capillaries were induced by hot and cold stimulation. The vasomotion and microvascular compliance were evaluated by the changes of blood flow velocity and time. The results of RHR blood pressure at the same time, microvascular reactivity was significantly reduced thermal stimulation, reactivity to cold stimulation increased to remove the maximum blood flow after stimulation returned to normal time delay, with serum angiotensin converting enzyme ( ACE) activity and nitrate / nitrite (NO) levels decreased. Enalapril can effectively improve these changes. CONCLUSIONS: RHR microvasculature is abnormally responsive to systolic and diastolic stimuli. Enalapril has a good effect of improving microvascular reactivity, and its mechanism is related to the maintenance of the integrity of endothelial function.