Despite medical treatment,the lethality of severe acutepancreatitis is still high (20-30%).Therefore,it is veryimportant to find good animal models to characterise theevents of this severe disease.In 1984,Mizunuma et al.developed a new type of experimental necrotizing pancreatitisby intraperitoneal administration of a high dose of L-argininein rats.This non-invasive model is highly reproducible andproduces selective,dose-dependent acinar cell necrosis.Not only is this a good model to study the pathomechanismsof acute necrotizing pancreatitis,but it is also excellent toobserve and influence the time course changes of thedisease.By writing this review we iluminate some newaspects of cell physiology and pathology of acute necrotizingpancreatitis.Unfortunately,the reviews about acuteexperimental pancreatitis usually did not discuss this model.Therefore,the aim of this manuscript was to summarisethe observations and address some challenges for the futurein L-arginine-induced pancreatitis. Despite the medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Thus, it is veryimportant to find good animal models to characterise theevents of this severe disease. In 1984, Mizunuma et al. Developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-argininein rats. This non-invasive model is highly reproducible andproduced selective, dose-dependent acinar cell necrosis. Not only is this a good model to study the pathomechanisms of acute necrotizing pancreatitis, but it is also excellent toobserve and influence the time course changes of the diseaseise.By writing this review we iluminate some newaspects of cell physiology and pathology of acute necrotizing pancreatic disease. Unfortunately, the reviews about acuteexperimental pancreatitis usually did not discuss this model.Therefore, the aim of this manuscript was to summarisethe observations and address some challenges for the futurein L-arginine-induced pancreatitis.