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目的:探讨血清C-反应蛋白(CRP)在糖尿病视网膜病变(DR)患者血清中的变化及临床价值。方法:90例2型糖尿病(T2DM)患者和45例健康查体者(对照组)为研究对象,根据眼底检查将90例T2DM患者分为糖尿病无视网膜病变组(无病变组),糖尿病视网膜病变组(病变组),测定血清CRP、糖化血红蛋白(HbAlc)水平及常规生化指标。结果:病变组、无病变组血清CRP和HbAlc水平显著高于对照组,且病变组血清CRP和HbAlc水平显著高于无病变组,相比较均有显著性差异(P<0.05);血清CRP、HbAlc水平为IV期>Ⅲ期>Ⅱ期>I期,各组间比较有显著性差异(P<0.05);DR患者血清CRP、HbAlc水平与糖尿病视网膜病变程度呈显著正相关(r=0.678,0.591;P<0.01)。结论:在糖尿病视网膜病变进程中,CRP起着非常重要的作用,CRP可以做为判定2型糖尿病患者发生DR的可靠指标。
Objective: To investigate the changes and clinical value of serum C-reactive protein (CRP) in the serum of patients with diabetic retinopathy (DR). Methods: 90 patients with type 2 diabetes (T2DM) and 45 healthy controls (control group) were included in the study. According to the fundus examination, 90 patients with T2DM were divided into two groups: diabetic retinopathy (non-lesion group), diabetic retinopathy (Disease group), serum CRP, HbAlc levels and routine biochemical indicators. Results: Serum levels of CRP and HbA1c in the diseased and non-diseased groups were significantly higher than those in the control group, and the levels of serum CRP and HbA1c in the diseased group were significantly higher than those in the non-diseased group (P <0.05). Serum CRP, The level of HbA1c was stage IV> stageⅢ> stageⅡ> stageⅠ, there was a significant difference between the groups (P <0.05). The levels of CRP and HbAlc in DR patients were positively correlated with the degree of diabetic retinopathy (r = 0.678, 0.591; P <0.01). Conclusion: CRP plays a very important role in the process of diabetic retinopathy. CRP can be used as a reliable indicator of DR in type 2 diabetic patients.